Scientists create lung cancer cells that use human stem cell function

According to a study published in the journal Nature Biotechnology indicates that scientists use human stem cells to create cells that function in the lungs and respiratory tract. The latest study, reported by the Columbia University Medical Center (CUMC), studied human lung development and produced lung tissue for transplantation. Researchers have relatively successfully turned to the differentiation of human stem cells into cardiac cells, pancreatic beta cells, intestinal cells, hepatocytes and nerve cells to increase the possibility of various regenerations, "Hans-Williams, professor of medical microbiology and immunology professor of research. Dr. SNOECK is finally able to make lung and airway cells, which is very important, because lung transplantation has a particularly bad phenomenon. Although it has been used for many years clinically, we can start to consider autologous lung transplantation, which is to use the patient's own skin Cellogenic function of lung tissue transplantation.

In 2011, SNOECK discovered a set of chemical factors that can differentiate human embryonic stem cells or human induced pluripotent stem cells into foregut endoderm. In the latest study, the research team found new factors to complete the transformation of human embryonic stem cells or iPS cells into normal lung epithelial cells.

The research team found that cells were found to express at least six types of lung and respiratory epithelial cells, with the distinctively labeled markers of type 2 alveolar epithelial cells. These type 2 cells are important because they produce key substances that maintain the alveoli where gas exchange occurs. These cells also help to repair the lungs after injury and injury.

The results of this study may have implications for some lung diseases, including idiopathic pulmonary fibrosis. No one knows what causes the disease and there is no way to treat it. Using this technique, researchers will eventually be able to create a laboratory model of IPF to study the disease at the molecular level that may be treated or cured. They hope to use this technique to make autogenous lung transplants. This treatment will need to be taken from the donor lungs, clearing all the lung-only stents left by the cells, and the desperate stent with the patient to derive new lung cells. This method helps to avoid the problem of rejection.

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