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In recent years, the most influential event in the field of Chinese medicine has apparently been Tuyou’s Nobel Prize. “Artemisinin†pushes the innovative achievements of TCM to the Hall of World Science and Technology Honor, and has further stimulated the interest of TCM at home and abroad. And enthusiasm. Nowadays, more attention and greater expectations have been placed on traditional Chinese medicine both at home and abroad, and it is an upsurge of “Nuggets†Chinese medicine. However, how can traditional Chinese medicine be crushed, and to what extent can it be pulverized to obtain higher efficacy and higher solubility?
The smashing of traditional Chinese medicines is mainly the operation of using mechanical force to crush large pieces of solid medicinal materials into pieces or fine powders of a suitable degree. It is also possible to use another method to smash the solid medicinal material into a fine powder, such as a low-temperature comminution, which is a method of smashing by means of the condition of the material to be crushed at a low temperature. The aim of Chinese medicine crushing is mainly to increase the surface area of ​​medicines in Chinese medicine bioengineering and pharmaceutical engineering, to promote the dissolution and absorption of medicines, to improve the bioavailability of medicines, to adapt to the application of a variety of administration routes, and to be effective in medicines. The intrusion or dissolution of substances provides raw materials for the preparation of various dosage forms, such as powders, granules, pills, tablets and the like, all of which are formed using nuisance powder and granules, and are also convenient for dispensing and taking.
It is understood that the most important application field of Chinese medicine ultrafine pulverizers is the traditional Chinese medicine. With the continuous maturation of Chinese medicine ultrafine pulverization technology, it will play an increasingly important role in the field of Chinese medicine pulverization. Hebei Medical University did a study to introduce ultra-micro-pulverization technology of traditional Chinese medicine on the basis of organic solvent extraction technology of Ginkgo biloba leaves, and investigated the effect of particle size, solvent dosage and extraction time on the yield of Ginkgo biloba extract. Results Compared with the control, the yield of flavonoid glycosides in Ginkgo biloba extract was increased from 1.15% to 1.71% when gingko leaves were crushed to an average particle size of 42μm, and the yield of ginkgolide was increased from 0.47% to 0.68%. Solvent consumption was reduced by 43%; leaching time can be selected by 30 minutes, saving 75%. The results show that ultra-micro-pulverization technology of traditional Chinese medicine can effectively improve the extraction process of Ginkgo biloba.
The good effect of Ginkgo biloba extract using traditional Chinese medicine ultramicro technology is just a case of plant extraction. As the highest-end product in the mill, the advantages of the Chinese medicine ultrafine crusher still need to be explored. The development of traditional Chinese medicine superfine pulverizers has now been going on for many years. From the initial imitation to the current innovation and research and development, from a single industry to the popularization of various related industries, the Chinese medicine superfine pulverizer now has a very powerful comminution ability through traditional Chinese medicine. After ultrafine comminution, traditional Chinese medicine can achieve a level of easy cell wall rupture. At this time, the absorption rate of traditional Chinese medicine will reach a greater increase. This technology has a bright future in the use of precious Chinese medicine, and it is important for the protection of rare Chinese medicine varieties and increase the utilization rate. Meaning, the same for the plant extract industry is also a good way to increase production efficiency and reduce production costs.
At present, the study of ultrafine pulverizers for traditional Chinese medicines is based on a large number of single-taste drugs, mainly focusing on whether to increase the dissolution rate, increase the bioavailability, reduce the dosage, and enhance pharmacological effects. It is reported that the heavy pressure grinding type ultrafine pulverizer YSC-701 has become a modern technology machine, and its high technological content has obvious effects on crushed fibrous materials such as Ganoderma lucidum, licorice, and buffalo horn. This also provides equipment support for improving the application of traditional Chinese medicine and developing new Chinese medicine preparations.
Chinese medicine ultrafine powder is an extension of traditional Chinese medicine coarse powder, but unlike the ultrafine powders of other industries, it should pay attention to many aspects when smashing traditional Chinese medicine. For example, the drug application site of Chinese medicine is complex, including various parts such as flowers, leaves, roots, stems, and whole plants. The nature of various parts varies greatly. From the cell level, layers from the outside to the inside, such as the cork layer Cortical, phloem, cambium, xylem, ray, etc. are composed of different types of cells, and their cell wall properties such as parenchyma cells, stone cells, catheters, wood fibers, and cork cells are different. Another example is the nature of different varieties of Chinese herbal medicines are different, such as Panax notoginseng hard, yellow soft and sticky essence, strong jaundice fiber and so on. The homogeneity of ultrafine powders of other varieties other than Panax pseudoginseng needs to be studied further from different ultrafine grinding techniques, evaluation indicators, and medicinal materials with different properties.
Traditional Chinese medicine pulverizers play an important role in the processing of traditional Chinese medicines, and they have also become popular in the pharmaceutical machinery market. However, the increasingly fierce market competition has made great changes in the prospects of the Chinese medicine crusher industry. In order to win a place in the market competition, manufacturers of traditional Chinese medicine shredders must seize the direction of industry development. For example, with the advent of the intelligent era, Chinese medicine crushers are also shifting toward the direction of intelligence, and more and more smart products will emerge.
The smashing of traditional Chinese medicines is mainly the operation of using mechanical force to crush large pieces of solid medicinal materials into pieces or fine powders of a suitable degree. It is also possible to use another method to smash the solid medicinal material into a fine powder, such as a low-temperature comminution, which is a method of smashing by means of the condition of the material to be crushed at a low temperature. The aim of Chinese medicine crushing is mainly to increase the surface area of ​​medicines in Chinese medicine bioengineering and pharmaceutical engineering, to promote the dissolution and absorption of medicines, to improve the bioavailability of medicines, to adapt to the application of a variety of administration routes, and to be effective in medicines. The intrusion or dissolution of substances provides raw materials for the preparation of various dosage forms, such as powders, granules, pills, tablets and the like, all of which are formed using nuisance powder and granules, and are also convenient for dispensing and taking.
It is understood that the most important application field of Chinese medicine ultrafine pulverizers is the traditional Chinese medicine. With the continuous maturation of Chinese medicine ultrafine pulverization technology, it will play an increasingly important role in the field of Chinese medicine pulverization. Hebei Medical University did a study to introduce ultra-micro-pulverization technology of traditional Chinese medicine on the basis of organic solvent extraction technology of Ginkgo biloba leaves, and investigated the effect of particle size, solvent dosage and extraction time on the yield of Ginkgo biloba extract. Results Compared with the control, the yield of flavonoid glycosides in Ginkgo biloba extract was increased from 1.15% to 1.71% when gingko leaves were crushed to an average particle size of 42μm, and the yield of ginkgolide was increased from 0.47% to 0.68%. Solvent consumption was reduced by 43%; leaching time can be selected by 30 minutes, saving 75%. The results show that ultra-micro-pulverization technology of traditional Chinese medicine can effectively improve the extraction process of Ginkgo biloba.
The good effect of Ginkgo biloba extract using traditional Chinese medicine ultramicro technology is just a case of plant extraction. As the highest-end product in the mill, the advantages of the Chinese medicine ultrafine crusher still need to be explored. The development of traditional Chinese medicine superfine pulverizers has now been going on for many years. From the initial imitation to the current innovation and research and development, from a single industry to the popularization of various related industries, the Chinese medicine superfine pulverizer now has a very powerful comminution ability through traditional Chinese medicine. After ultrafine comminution, traditional Chinese medicine can achieve a level of easy cell wall rupture. At this time, the absorption rate of traditional Chinese medicine will reach a greater increase. This technology has a bright future in the use of precious Chinese medicine, and it is important for the protection of rare Chinese medicine varieties and increase the utilization rate. Meaning, the same for the plant extract industry is also a good way to increase production efficiency and reduce production costs.
At present, the study of ultrafine pulverizers for traditional Chinese medicines is based on a large number of single-taste drugs, mainly focusing on whether to increase the dissolution rate, increase the bioavailability, reduce the dosage, and enhance pharmacological effects. It is reported that the heavy pressure grinding type ultrafine pulverizer YSC-701 has become a modern technology machine, and its high technological content has obvious effects on crushed fibrous materials such as Ganoderma lucidum, licorice, and buffalo horn. This also provides equipment support for improving the application of traditional Chinese medicine and developing new Chinese medicine preparations.
Chinese medicine ultrafine powder is an extension of traditional Chinese medicine coarse powder, but unlike the ultrafine powders of other industries, it should pay attention to many aspects when smashing traditional Chinese medicine. For example, the drug application site of Chinese medicine is complex, including various parts such as flowers, leaves, roots, stems, and whole plants. The nature of various parts varies greatly. From the cell level, layers from the outside to the inside, such as the cork layer Cortical, phloem, cambium, xylem, ray, etc. are composed of different types of cells, and their cell wall properties such as parenchyma cells, stone cells, catheters, wood fibers, and cork cells are different. Another example is the nature of different varieties of Chinese herbal medicines are different, such as Panax notoginseng hard, yellow soft and sticky essence, strong jaundice fiber and so on. The homogeneity of ultrafine powders of other varieties other than Panax pseudoginseng needs to be studied further from different ultrafine grinding techniques, evaluation indicators, and medicinal materials with different properties.
Traditional Chinese medicine pulverizers play an important role in the processing of traditional Chinese medicines, and they have also become popular in the pharmaceutical machinery market. However, the increasingly fierce market competition has made great changes in the prospects of the Chinese medicine crusher industry. In order to win a place in the market competition, manufacturers of traditional Chinese medicine shredders must seize the direction of industry development. For example, with the advent of the intelligent era, Chinese medicine crushers are also shifting toward the direction of intelligence, and more and more smart products will emerge.
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